Sanchez Martin-Fontecha Elena

Sanchez Martin-Fontecha Elena - Postdoctoral fellow

Elena obtained her PhD in 2021 under the supervision of Dr. Pilar Cubas at the National Centre for Biotechnology (CNB-CSIC) in Madrid, Spain. Her research focused on strigolactone signalling in Arabidopsis, specifically studying the degradation of the strigolactone receptor AtD14 and its role in plant development. After completing her PhD, she joined Prof. Inge De Clercq’s lab, which focuses on Inter-organelle Stress Signalling, as a postdoctoral scientist. Currently, Elena holds a Marie Curie Postdoctoral Fellowship, aiming to unravel the interactions between chloroplasts, the endoplasmic reticulum (ER), and mitochondria, with the goal of identifying the complex molecular mechanisms involved in inter-organelle communication.

De Clercq Inge

De Clercq Inge - Junior Group leader

Inter-organelle Stress Signalling

To be able to survive constantly changing and often harmful environmental conditions, plants must continuously adapt. Therefore, plants have complex mechanisms that sense and transduce environmental stimuli into adaptive and defence responses. Organelles within the cell are thought to be important sensors of such stresses, such as water limitation or pathogen attack. They communicate their stressed status with the nucleus to activate tolerance mechanisms and defence responses against the incoming stresses. We have previously revealed a novel mechanism of how mitochondria, chloroplasts, and the endoplasmic reticulum communicate stress signals to coordinate stress signal transduction into adaptive responses in the nucleus. However, we still lack a profound mechanistic understanding of how organelles cooperate with each other during stress responses. The signalling sources within the organelles, their release and/or propagation, and their perception by other organelles and eventually by the nucleus are still enigmatic. Therefore, the Inter-organelle Stress Signalling team performs studies to understand the complex organelle-organelle and organelle-to-nucleus cross-talk using high-end multi-omics and cell biology approaches.

How pathogens counterattack

How pathogens counterattack

In order to obtain specific and sustainable solutions for crop protection, we need a better understanding of the molecular interactions between plants and phytopathogens. Intracellular organelles such as chloroplasts and mitochondria play a pivotal role in plant immune responses. Our team aims to identify pathogen-secreted effector proteins that target the plant host organelles.

Understanding inter-organellar communication by contact sites

Understanding inter-organellar communication by contact sites

Due to their tight integration into the cell’s metabolic and signaling networks, organelles are in a prime position to communicate stress signals and coordinate optimal adaptive responses. However, we lack a profound understanding of how these organelles communicate stress signals with each other. In our lab we study a novel mechanism of communication between organelles, more specifically, by their direct physical association, through the identification of stress-induced contact sites with the use of state-of-the-art live-cell imaging and proteomics methods.

VIB welcomes MSCA fellows

The Marie Sklodowska-Curie Actions of the EU offer postdoctoral fellowships to talented researchers. These MSCA fellowships provide an opportunity for young scientists to conduct research in foreign countries, gain expertise, and advance their professional pursuits. VIB is pleased to welcome four new Marie Curie fellows this year.

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